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Expression analyses of nanos(RNAi) and control(RNAi) Schmidtea mediterranea

ABSTRACT: Investigation of whole genome gene expression level changes in nanos(RNAi) Schmidtea mediterranea, compared to control animals. nanos(RNAi) animals are devoid of germ cells The samples analyzed in this study are further described in Wang, Y., Stary, JM., Wilhelm, JE. and Newmark, PA. 2010. A eight chip study using total RNA recovered from asexual nanos(RNAi), asexual control, juvenile sexual nanos(RNAi), and juvenile sexual control animals. Each chip measures the expression level of 16,797 ESTs from S. mediterranea with 10 60-mer probe pairs (PM/MM) per gene, with two-fold technical redundancy.

ORGANISM(S): Schmidtea mediterranea

SUBMITTER: Phillip Newmark 

PROVIDER: E-GEOD-22797 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A functional genomic screen in planarians identifies novel regulators of germ cell development.

Wang Yuying Y   Stary Joel M JM   Wilhelm James E JE   Newmark Phillip A PA  

Genes & development 20100901 18

Germ cells serve as intriguing examples of differentiated cells that retain the capacity to generate all cell types of an organism. Here we used functional genomic approaches in planarians to identify genes required for proper germ cell development. We conducted microarray analyses and in situ hybridization to discover and validate germ cell-enriched transcripts, and then used RNAi to screen for genes required for discrete stages of germ cell development. The majority of genes we identified enco  ...[more]

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