Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yuk Ming Lo
PROVIDER: E-GEOD-22837 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Tsui Dana W Y DW Lam Y M Doris YM Lee Wing S WS Leung Tak Y TY Lau Tze K TK Lau Elizabeth T ET Tang Mary H Y MH Akolekar Ranjit R Nicolaides Kypros H KH Chiu Rossa W K RW Lo Y M Dennis YM Chim Stephen S C SS
PloS one 20101130 11
<h4>Background</h4>Noninvasive prenatal diagnosis of fetal aneuploidy by maternal plasma analysis is challenging owing to the low fractional and absolute concentrations of fetal DNA in maternal plasma. Previously, we demonstrated for the first time that fetal DNA in maternal plasma could be specifically targeted by epigenetic (DNA methylation) signatures in the placenta. By comparing one such methylated fetal epigenetic marker located on chromosome 21 with another fetal genetic marker located on ...[more]