Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Erdogan Taskesen
PROVIDER: E-GEOD-22845 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Taskesen Erdogan E Bullinger Lars L Corbacioglu Andrea A Sanders Mathijs A MA Erpelinck Claudia A J CA Wouters Bas J BJ van der Poel-van de Luytgaarde Sonja C SC Damm Frederik F Krauter Jürgen J Ganser Arnold A Schlenk Richard F RF Löwenberg Bob B Delwel Ruud R Döhner Hartmut H Valk Peter J M PJ Döhner Konstanze K
Blood 20101221 8
We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures of CCAAT/enhancer binding protein alpha (CEBPA) double mutations (CEBPA(dm)) versus single mutations (CEBPA(sm)) in 1182 cytogenetically normal acute myeloid leukemia (AML) patients (16-60 years of age). We identified 151 (12.8%) patients with CEBPA mutations (91 CEBPA(dm) and 60 CEBPA(sm)). The incidence of germline mutations was 7% (5 of 71), including 3 C-terminal mutations. CEBPA(dm) patients had a lower ...[more]