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DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas

ABSTRACT: Elevated DNA methylation in the first intronic region of the BCL6 locus in B cell lymphomas enforces transcription of the BCL6 gene Promoter tiling arrays were used to investigate the distribution of DNA methylation near the promoter region of BCL6 locus Comparison of DNA methylation at promoter regions of lymphoma (Raji) and myeloma (H929) cell lines by methylated CpG island recovery assay (MIRA-chip)

ORGANISM(S): Homo sapiens

SUBMITTER: Deepak Mav

PROVIDER: E-GEOD-22884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas.

Lai Anne Y AY Fatemi Mehrnaz M Dhasarathy Archana A Malone Christine C Sobol Steve E SE Geigerman Cissy C Jaye David L DL Mav Deepak D Shah Ruchir R Li Leping L Wade Paul A PA

The Journal of experimental medicine 20100823 9

Aberrant DNA methylation commonly occurs in cancer cells where it has been implicated in the epigenetic silencing of tumor suppressor genes. Additional roles for DNA methylation, such as transcriptional activation, have been predicted but have yet to be clearly demonstrated. The BCL6 oncogene is implicated in the pathogenesis of germinal center-derived B cell lymphomas. We demonstrate that the intragenic CpG islands within the first intron of the human BCL6 locus were hypermethylated in lymphoma ...[more]

PMID: 20733034

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