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Transcriptome profiling of genes regulated by RXR and its partners in monocyte-derived dendritic cells

ABSTRACT: CD14+ human monocytes differentiating into DCs in the presence of IL4 and GM-CSF were treated with agonists for RXR and its partners or vehicle 18 hours after plating (experiment with RXR and permissive partners, donor 1-3) or 14 hours after plating (experiment with nonpermissive partners, donor 4-6). Cells were harvested 12 hours thereafter. Experiments were performed in biological triplicates representing samples from three different donors.  In this study all probable RXR-signaling pathways induced by agonists for RXR, LXRs, PPARs, RAR and VDR were identified in differentiating human monocyte-derived dendritic cells. In the experiments, differentiating dendritic cells were treated for 12 hours with one of the following compounds (ligands): vehicle (DMS:EtOH 1:1) LG268 (RXR agonist) 9-cis retinoic acid (9cisRA, agonist of RAR and RXR) GW3965 (LXRalpha/beta panagonist) rosiglitazone (RSG, PPARgamma agonist)  GW1516 (PPARdelta agonist) AM580 (RARalpha agonist) 1,25-dihydroxyvitamin D3 (VDR agonist)

ORGANISM(S): Homo sapiens

SUBMITTER: LAJOS SZELES 

PROVIDER: E-GEOD-23073 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells.

Széles Lajos L   Póliska Szilárd S   Nagy Gergely G   Szatmari Istvan I   Szanto Attila A   Pap Attila A   Lindstedt Malin M   Santegoets Saskia J A M SJ   Rühl Ralph R   Dezsö Balázs B   Nagy László L  

Molecular endocrinology (Baltimore, Md.) 20100922 11

Retinoid X receptors (RXRs) are heterodimerization partners for many nuclear receptors and also act as homodimers. Heterodimers formed by RXR and a nonpermissive partner, e.g. retinoic acid receptor (RAR) and vitamin D receptor (VDR), can be activated only by the agonist of the partner receptor. In contrast, heterodimers that contain permissive partners, e.g. liver X receptor (LXR) and peroxisome proliferator-activated receptor (PPAR), can be activated by agonists for either the partner receptor  ...[more]

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