Transcriptomics

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Transcriptome profiling of genes regulated by RXR and its partners in monocyte-derived dendritic cells


ABSTRACT: CD14+ human monocytes differentiating into DCs in the presence of IL4 and GM-CSF were treated with agonists for RXR and its partners or vehicle 18 hours after plating (experiment with RXR and permissive partners, donor 1-3) or 14 hours after plating (experiment with nonpermissive partners, donor 4-6). Cells were harvested 12 hours thereafter. Experiments were performed in biological triplicates representing samples from three different donors.  In this study all probable RXR-signaling pathways induced by agonists for RXR, LXRs, PPARs, RAR and VDR were identified in differentiating human monocyte-derived dendritic cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE23073 | GEO | 2010/09/01

SECONDARY ACCESSION(S): PRJNA131679

REPOSITORIES: GEO

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