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Oncogene activation induces metabolic transformation resulting in insulin independence in human breast cancer cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Aliccia Bollig-Fischer

PROVIDER: E-GEOD-23176 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells.

Bollig-Fischer Aliccia A Dewey T Gregory TG Ethier Stephen P SP

PloS one 20110317 3

Normal breast epithelial cells require insulin and EGF for growth in serum-free media. We previously demonstrated that over expression of breast cancer oncogenes transforms MCF10A cells to an insulin-independent phenotype. Additionally, most breast cancer cell lines are insulin-independent for growth. In this study, we investigated the mechanism by which oncogene over expression transforms MCF10A cells to an insulin-independent phenotype. Analysis of the effects of various concentrations of insu ...[more]

PMID: 21437235

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