Unknown,Transcriptomics,Genomics,Proteomics

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Expression profile for Drosophila Sox14 at onset of metamorphosis


ABSTRACT: We used microarray analysis of RNA obtained from w1118 and w1118;sox14L1/sox14L1 animals staged at pupariation to identify genes regulated by Drosophila Sox14 at the onset of metamorphosis. RNA isolated from whole Drosophila w1118 and w1118; sox14L1/sox14L1 animals selected immediately after pupariation was hybridized on Affymetrix Drosophila Genome 2.0 Arrays. Each genotype was assayed independently three times with samples obtained from 10 prepupae.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Robert Beckstead 

PROVIDER: E-GEOD-23355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis.

Ritter Amanda R AR   Beckstead Robert B RB  

Developmental dynamics : an official publication of the American Association of Anatomists 20101001 10


The steroid hormone 20-hydroxyecdysone (20E), by means of a heterodimer consisting of two nuclear receptors, the Ecdysone receptor (EcR) and Ultraspiracle (Usp), triggers the major developmental transitions in the Drosophila life cycle through the regulation of genetic hierarchies. We have previously demonstrated that the Sox14 transcription factor is a primary response gene to 20E/EcR/Usp complex. In this study, we show that mutations in sox14 result in prepupal and pupal lethality with animals  ...[more]

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