Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Karl Dykema
PROVIDER: E-GEOD-23435 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Diegel Cassandra R CR Cho Kathleen R KR El-Naggar Adel K AK Williams Bart O BO Lindvall Charlotta C
Cancer research 20101109 22
Cross-talk between the canonical Wnt and mammalian target of rapamycin (mTOR) signaling pathways occurs at multiple levels in the cell and likely contributes to the oncogenic effects of these pathways in human cancer. To gain more insight into the interplay between Wnt and mTOR signaling in salivary gland tumorigenesis, we developed a mouse model in which both pathways are constitutively activated by the conditional inactivation of the Apc and Pten tumor suppressor genes. Loss of either Apc or P ...[more]