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Gene expression data from AKT induced salivary gland tumors

ABSTRACT: Rapamycin treatment of AKT induced salivary gland tumors Normal tissue (parotid and submandibular), untreated tumor tissue, and tumor tissue treated for 3/14 days

ORGANISM(S): Mus musculus

SUBMITTER: Karl Dykema

PROVIDER: E-GEOD-23435 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.

Diegel Cassandra R CR Cho Kathleen R KR El-Naggar Adel K AK Williams Bart O BO Lindvall Charlotta C

Cancer research 20101109 22

Cross-talk between the canonical Wnt and mammalian target of rapamycin (mTOR) signaling pathways occurs at multiple levels in the cell and likely contributes to the oncogenic effects of these pathways in human cancer. To gain more insight into the interplay between Wnt and mTOR signaling in salivary gland tumorigenesis, we developed a mouse model in which both pathways are constitutively activated by the conditional inactivation of the Apc and Pten tumor suppressor genes. Loss of either Apc or P ...[more]

PMID: 21062985

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