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Mapping differences in salivary gland secretions using dried saliva spots

ABSTRACT: Dried saliva spot (DSS) sampling is a minimally invasive extraction technique that allows for the spatial mapping of salivary protein distribution in the oral cavity. In conjunction with untargeted nanoLC-Orbitrap-MS/MS analysis, we used DSS to compare the unstimulated proteomes secreted by the parotid and submandibular/sublingual salivary glands

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

SUBMITTER: Markus Hardt

LAB HEAD: Markus Hardt

PROVIDER: PXD012792 | Pride | 2019-09-04

REPOSITORIES: Pride

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			Action	DRS
	20171120_PGL1.raw	Raw
	20171120_PGL2.raw	Raw
	20171120_PGL3.raw	Raw
	20171120_PGR1.raw	Raw
	20171120_PGR2.raw	Raw

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Publications

Mapping Relative Differences in Human Salivary Gland Secretions by Dried Saliva Spot Sampling and nanoLC-MS/MS.

Schulte Fabian F Hasturk Hatice H Hardt Markus M

Proteomics 20190926 20

Dried saliva spot sampling is a minimally invasive technique for the spatial mapping of salivary protein distribution in the oral cavity. In conjunction with untargeted nano-flow liquid chromatography tandem mass spectrometry (nanoLC-MS/MS) analysis, DSS is used to compare the proteomes secreted by unstimulated parotid and submandibular/sublingual salivary glands. Two hundred and twenty proteins show a statistically significant association with parotid gland secretion, while 30 proteins are at l ...[more]

PMID: 31476108

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