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Circadian cycling of genome-wide histone methylation

ABSTRACT: Daily (circadian) clocks are essential for regulating and coordinating physiology in mammals. Modulation of local chromatin structure has been shown for only a small number of genes, principally thought to be directly modulated by Clock-mediated histone acetylation. Here we show that genome-wide changes of active and suppressive histone marks control global chromatin architecture over the day and night. Examination of mouse liver tissue at 4 time-points around the clock in "free-running", continuous conditions (constant darkness, temperature and food available ad libitum).

ORGANISM(S): Mus musculus

SUBMITTER: Akhilesh Reddy

PROVIDER: E-GEOD-23550 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.

Valekunja Utham K UK Edgar Rachel S RS Oklejewicz Malgorzata M van der Horst Gijsbertus T J GT O'Neill John S JS Tamanini Filippo F Turner Daniel J DJ Reddy Akhilesh B AB

Proceedings of the National Academy of Sciences of the United States of America 20130107 4

Daily cyclical expression of thousands of genes in tissues such as the liver is orchestrated by the molecular circadian clock, the disruption of which is implicated in metabolic disorders and cancer. Although we understand much about the circadian transcription factors that can switch gene expression on and off, it is still unclear how global changes in rhythmic transcription are controlled at the genomic level. Here, we demonstrate circadian modification of an activating histone mark at a signi ...[more]

PMID: 23297224

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