Daily cycling of genome-wide histone methylation
Ontology highlight
ABSTRACT: Daily (circadian) clocks are essential for regulating and coordinating physiology in mammals. Modulation of local chromatin structure has been shown for only a small number of genes, principally thought to be directly modulated by Clock-mediated histone acetylation. Here we show that genome-wide changes of active and suppressive histone marks control global chromatin architecture over the day and night. Examination of mouse liver tissue at 4 time-points around the clock in "free-running", continuous conditions (constant darkness, temperature and food available ad libitum).
ORGANISM(S): Mus musculus
SUBMITTER: Utham Valekunja
PROVIDER: E-GEOD-37393 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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