Dataset Information

Matrix Remodelling during Lymph Node Expansion

ABSTRACT: In this study we focussed our investigations on ECM remodelling by FRCs during lymph node (LN) expansion, and the interconnection between the cellular and ECM components of the conduit network. We demonstrate a loss of ECM components of the conduit during acute LN expansion

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Fibroblast

SUBMITTER: Lukas Krasny

LAB HEAD: Paul Huang

PROVIDER: PXD015816 | Pride | 2021-05-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20180511_DDA_WT1.group	Other
	20180511_DDA_WT1_R1.wiff	Wiff
	20180511_DDA_WT1_R1.wiff.scan	Wiff
	20180511_DDA_WT1_R2.wiff	Wiff
	20180511_DDA_WT1_R2.wiff.scan	Wiff

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Publications

Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion.

Martinez Victor G VG Pankova Valeriya V Krasny Lukas L Singh Tanya T Makris Spyridon S White Ian J IJ Benjamin Agnesska C AC Dertschnig Simone S Horsnell Harry L HL Kriston-Vizi Janos J Burden Jemima J JJ Huang Paul H PH Tape Christopher J CJ Acton Sophie E SE

Cell reports 20191101 9

Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs undergo rapid 3- to 5-fold expansion during adaptive immune responses, but these ECM-rich structures are not permanently damaged. Whether conduit flow or filtering function is affected during LN expansion is unknown. Here, we show that conduits are partially disru ...[more]

PMID: 31775047

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