Unknown,Transcriptomics,Genomics,Proteomics

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Expression data of SW480 cells with TFAP2E overexpression and without TFAP2E (empty vector control)

ABSTRACT: AP2 transcription factors play important roles in development and cancer, we tried to clarify the role of the so far uncharacterised TFAP2E in colorectal cancer. We used GENE ST 1.0 Arrays to detail up and downregulated target genes of this AP-2 transcription factor. We used the ptarget mammalian expression vector (Promega) to overexpress the TFAP2E gene in the SW480 CRC line.

ORGANISM(S): Homo sapiens

SUBMITTER: Marc Taenzer 

PROVIDER: E-GEOD-23698 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Background</h4>Chemotherapy for advanced colorectal cancer leads to improved survival; however, predictors of response to systemic treatment are not available. Genomic and epigenetic alterations of the gene encoding transcription factor AP-2 epsilon (TFAP2E) are common in human cancers. The gene encoding dickkopf homolog 4 protein (DKK4) is a potential downstream target of TFAP2E and has been implicated in chemotherapy resistance. We aimed to further evaluate the role of TFAP2E and DKK4 as p  ...[more]

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