Unknown,Transcriptomics,Genomics,Proteomics

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DNA methylation data from non-immortalized lymphocyte samples from participants of the AGES Reykjavik Study

ABSTRACT: Genome-wide DNA methylation was studied to identify regions with extreme inter-individual variability, half of which show stability within-person, and some of which show covariation with body mass index consistently and are located in or near genes previously implicated in regulating body weight or diabetes. We isolated genomic DNA from non-immortalized lymphocyte samples from participants of the AGES Reykjavik Study and hybridized it to custom-designed NimbleGen microarrays (CHARM arrays).

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Murakami 

PROVIDER: E-GEOD-23858 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Personalized epigenomic signatures that are stable over time and covary with body mass index.

Feinberg Andrew P AP   Irizarry Rafael A RA   Fradin Delphine D   Aryee Martin J MJ   Murakami Peter P   Aspelund Thor T   Eiriksdottir Gudny G   Harris Tamara B TB   Launer Lenore L   Gudnason Vilmundur V   Fallin M Daniele MD  

Science translational medicine 20100901 49

The epigenome consists of non-sequence-based modifications, such as DNA methylation, that are heritable during cell division and that may affect normal phenotypes and predisposition to disease. Here, we have performed an unbiased genome-scale analysis of ~4 million CpG sites in 74 individuals with comprehensive array-based relative methylation (CHARM) analysis. We found 227 regions that showed extreme interindividual variability [variably methylated regions (VMRs)] across the genome, which are e  ...[more]

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