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Epigenetic profile of the Plasmodium falciparum intraerythrocytic cycle

ABSTRACT: This experiment characterizes the localisation of H2A.Z, H3K9ac and H3K4me3 in the epigenome of the human malaria parasite, P. falciparum at 4 different stages of intraerythrocytic development. Examination of H2A.Z, H3K9ac, H3K4me3 and mono-nucleosomal input in 3D7 strain at 4 different stages and H2A in 3D7 strain at 1 stage using native ChIP-seq

ORGANISM(S): Plasmodium falciparum 3D7

SUBMITTER: H. Stunnenberg

PROVIDER: E-GEOD-23867 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3.

Bártfai Richárd R Hoeijmakers Wieteke A M WA Salcedo-Amaya Adriana M AM Smits Arne H AH Janssen-Megens Eva E Kaan Anita A Treeck Moritz M Gilberger Tim-Wolf TW Françoijs Kees-Jan KJ Stunnenberg Hendrik G HG

PLoS pathogens 20101216 12

Epigenetic regulatory mechanisms and their enzymes are promising targets for malaria therapeutic intervention; however, the epigenetic component of gene expression in P. falciparum is poorly understood. Dynamic or stable association of epigenetic marks with genomic features provides important clues about their function and helps to understand how histone variants/modifications are used for indexing the Plasmodium epigenome. We describe a novel, linear amplification method for next-generation seq ...[more]

PMID: 21187892

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