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MicroRNA expression in lymphoma lines

ABSTRACT: MicroRNAs from lymphoma and leukemia cell lines with or without the 13q31 amplicon were quantitated using a custom microarray platform. 5ug total RNA from each line was labeled with cy3 and hybridized to a microarray that contains probes to 238 mouse and human mature microRNAs. Four data sets per cell line are provided. Data is presented as log (base 2) values median center normalized. Keywords: other

ORGANISM(S): Homo sapiens

SUBMITTER: Scott Hammond

PROVIDER: E-GEOD-2399 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A microRNA polycistron as a potential human oncogene.

He Lin L Thomson J Michael JM Hemann Michael T MT Hernando-Monge Eva E Mu David D Goodson Summer S Powers Scott S Cordon-Cardo Carlos C Lowe Scott W SW Hannon Gregory J GJ Hammond Scott M SM

Nature 20050601 7043

To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these can ...[more]

PMID: 15944707

Similar Datasets

MicroRNA expression in lymphoma lines

Project description:MicroRNAs from lymphoma and leukemia cell lines with or without the 13q31 amplicon were quantitated using a custom microarray platform. 5ug total RNA from each line was labeled with cy3 and hybridized to a microarray that contains probes to 238 mouse and human mature microRNAs. Four data sets per cell line are provided. Data is presented as log (base 2) values median center normalized. Keywords: other

2005-03-31 | GSE2399 | GEO

MicroRNA microarray analysis in nasal NK/T-cell lymphoma cell lines

Project description:Gene expression profiling of 1,211 microRNAs in nasal NK/T-cell lymphoma cell lines Gene expression profiling of 1,211 microRNAs in three nasal NK/T-cell lymphoma cell lines, EBV-negative NK-cell line and normal NK cells

2014-02-01 | E-GEOD-43958 | biostudies-arrayexpress

Expression data from Burkitt lymphoma cases

Project description:Burkitt lymphoma is the commonest cancer in children in Africa. We compared the gene expression profiles of African Burkitt lymphoma patients with those of cases presented in Western countries in both immunocompetent (sporadic Burkitt lymphoma) and HIV-infected patients (immunodeficiency associated Burkitt lymphoma). We used microarrays to detail the global programme of gene expression in different subtypes of Burkitt lymphoma.

2011-01-20 | GSE26673 | GEO

MicroRNA profiles of RISC sub-complexes

Project description:293 cells were tranfected with Myc-tagged argonaute family members and associated microRNAs quantitated by microarray analysis of immunoprecipitates. Human argonaute 1, 2, and 3, and a control immunoprecipitation were done. Two independent immunoprecipitations were performed, with two replicate points per immunoprecipitation. Ch1and Ch2 net values are median intensity, background subtracted, unnormalized. Normalized Ch2 values for argonaute immunoprecipitations are median center normalized. Normalized Ch2 values for control immunoprecipitates are normalized by a constant that is the average of the constants used for argonaute immunoprecipitates. Keywords = microRNA Keywords = miRNA Keywords = argonaute Keywords = RNAi Keywords: repeat sample

2004-07-30 | GSE1573 | GEO

Transcription profiling of Burkitt lymphoma cases

2011-01-20 | E-GEOD-26673 | biostudies-arrayexpress

Comparative genomic hybridization of human Burkitts lymphoma samples

Project description:Additional chromosomal abnormalities are currently detected in Burkitts lymphoma. They play major roles in the progression of BL and in prognosis. The genes involved remain elusive. A whole-genome oligonucleotide array CGH analysis correlated with karyotype and FISH was performed in a set of 15 Burkitts lymphoma-derived cell lines ( in dye_swap with Human CGH 44K (G4410B) and Human CGH 244K (G4411B) ) and 12 primary tumors with Human CGH 44K (G4410B) . More than half of the 145 CNAs <2 Mb were mapped to Mendelian CNVs, including GSTT1, glutathione s-transferase T1, and BIRC6, an anti-apoptotic protein, possibly predisposing to some cancers. Somatic cell line-specific CNVs localized to the IG locus were consistently observed with the 244 K aCGH platform. Among 136 CNAs > 2 Mb, gains were found in 1q (12/27), 13q (7/27), 7q (6/27), 8q(4/27), 2p (3/27), 11q (2/27) and 15q (2/27). Losses were found in 3p (5/27), 4p (4/27), 4q (4/27), 9p (4/27), 13q (4/27), 6p (3/27), 17p (3/27), 6q (2/27),11pterp13 (2/27) and 14q12q21.3 (2/27). Twenty one minimal critical regions (MCR), (range 0.04-71.36 Mb), were delineated in tumors and cell lines. Three MCRs were localized to 1q. The proximal one was mapped to 1q21.1q25.2 with a 6.3 Mb amplicon (1q21.1q21.3) harboring BCA2 and PIAS3. In the other 2 MCRs, 1q32.1 and 1q44, MDM4 and AKT3 appeared as possible drivers of these gains respectively. The 13q31.3q32.1 <89.58-96.81> MCR contained an amplicon and ABCC4 might be the driver of this amplicon. The 40 Kb 2p16.1 <60.96-61> MCR was the smallest gained MCR and specifically encompassed the REL oncogene which is already implicated in B cell lymphomas. The most frequently deleted MCR was 3p14.1 <60.43-60.53> that removed the fifth exon of FHIT. Further investigations which combined gene expression and functional studies are essential to understand the lymphomagenesis mechanism and for the development of more effective, targeted therapeutic strategies

2009-09-18 | E-TABM-703 | biostudies-arrayexpress

Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma

Project description:The epigenome is often deregulated in cancer and treatment with inhibitors of bromodomain and extra-terminal proteins, the readers of epigenetic acetylation marks, represents a novel therapeutic approach. Here, we have characterized the anti-tumour activity of the novel bromodomain and extra-terminal (BET) inhibitor BAY 1238097 in preclinical lymphoma mod- els. BAY 1238097 showed anti-proliferative activity in a large panel of lym- phoma-derived cell lines, with a median 50% inhibitory concentration between 70 and 208 nmol/l. The compound showed strong anti-tumour efficacy in vivo as a single agent in two diffuse large B cell lymphoma mod- els. Gene expression profiling showed BAY 1238097 targeted the NFKB/ TLR/JAK/STAT signalling pathways, MYC and E2F1-regulated genes, cell cycle regulation and chromatin structure. The gene expression profiling sig- natures also highly overlapped with the signatures obtained with other BET Bromodomain inhibitors and partially overlapped with HDAC-inhibitors, mTOR inhibitors and demethylating agents. Notably, BAY 1238097 presented in vitro synergism with EZH2, mTOR and BTK inhibitors. In conclusion, the BET inhibitor BAY 1238097 presented promising anti-lym- phoma preclinical activity in vitro and in vivo, mediated by the interference with biological processes driving the lymphoma cells. Our data also indicate the use of combination schemes targeting EZH2, mTOR and BTK along- side BET bromodomains.

2017-09-05 | GSE93032 | GEO

MicroRNA profiles of RISC sub-complexes

2010-10-08 | E-GEOD-1573 | biostudies-arrayexpress

Affymetrix Genome-Wide Human SNP Array 6.0 data for Type II Enteropathy-associated T-cell lymphoma

Project description:Type II Enteropathy-associated T-cell lymphoma (Type II EATL) is an aggressive intestinal T-cell lymphoma with poor prognosis and has not been molecularly profiled. Through targeted amplicon sequencing, we identified a large portion of Type II EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Genome-wide DNA copy number profiling of Type II EATL tumors and matched normal samples was performed to determine copy-number changes in this disease.

2016-03-03 | GSE70653 | GEO

Mantle cell lymphoma gene expression profiling array UPF1.

Project description:The dataset contains data from 9 samples hybridized on Illumina HumanHT-12 array. -patient's primary lymphoma cells obtained from leukemized blood (P7-PBMC) -non-malignant B-cells isolated from peripheral blood of 5 healthy donors (CTRL) -lymphoma cell line named UPF1G established from the patient's primary lymphoma cells before cytarabine-based therapy after 63 and 163 days of in vitro cultivation (UPF1G-D63, UPF1G-D163) -lymphoma cell line named UPF1H established from the pateint's primary lymphoma cells after cytarabine-based therapy after 85 and 185 days of in vitro cultivation (UPF1H-D85, UPF1H-D185) -cells established by xenotransplantation of UPF1G cell line isolated ex vivo from subcutaneously growing lymphoma (UPF1G-SC) -cells established by xenotransplantation of UPF1G cell line isolated ex vivo from malignant murine ascites (UPF1G-A) -cells established by xenotransplantation of UPF1H cell line isolated ex vivo from subcutaneously growing lymphoma (UPF1H-SC) Samples were sorted using CD19-microbeads (Miltenyi). For xenotransplantation, NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice (referred to as NSG mice) were used.

2017-02-24 | GSE95292 | GEO

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