Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Nataly Cabili
PROVIDER: E-GEOD-24181 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Loewer Sabine S Cabili Moran N MN Guttman Mitchell M Loh Yuin-Han YH Thomas Kelly K Park In Hyun IH Garber Manuel M Curran Matthew M Onder Tamer T Agarwal Suneet S Manos Philip D PD Datta Sumon S Lander Eric S ES Schlaeger Thorsten M TM Daley George Q GQ Rinn John L JL
Nature genetics 20101107 12
The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by reprogramming is accompanied by a global remodeling of the epigenome, resulting in altered patterns of gene expression. Here we characterize the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occurs upon derivation of human iPSCs and identify numerous lincRNAs whose expression is linked to pluripotency. Among these, we defined ten lincRNAs whose expression was elevated in iP ...[more]