Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Wotton
PROVIDER: E-GEOD-24225 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zerlanko Brad J BJ Bartholin Laurent L Melhuish Tiffany A TA Wotton David D
PloS one 20120413 4
Transforming growth factor β (TGFβ) signaling regulates cell cycle progression in several cell types, primarily by inducing a G1 cell cycle arrest. Tgif1 is a transcriptional corepressor that limits TGFβ responsive gene expression. Here we demonstrate that primary mouse embryo fibroblasts (MEFs) lacking Tgif1 proliferate slowly, accumulate increased levels of DNA damage, and senesce prematurely. We also provide evidence that the effects of loss of Tgif1 on proliferation and senescence are not li ...[more]