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Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress

ABSTRACT: We compared microRNA (miRNA) expression in Ercc1-/- primary mouse embryonic fibroblasts (MEFs) and wild-type (WT) MEFs in 20% O2 and 3% O2 growth conditions to identify miRNAs that drive cellular senescence. MicroRNA expression in WT and Erccc1-/- MEFs was measured at passage 3 and passage 7 after growth in 20% and 3% O2. Two independent experiments were performed for each growth condition.

ORGANISM(S): Mus musculus

SUBMITTER: Saleem Khan

PROVIDER: E-GEOD-48417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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