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Unknown,Transcriptomics,Genomics,Proteomics

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Mouse tissue-resident macrophage expression profiles

ABSTRACT: We show that macrophages from murine spleen, liver and peritoneum display dramatically different expression profiles. Clusters of genes were found to represent unique biological functions related to adhesion, antigen presentation, phagocytosis, lipid metabolism and signal transduction. Some gene families, such as integrins, are differentially expressed among the macrophages resident in different tissues, suggesting that the tissue of residence influences their biological function. 18 FACS sorted mouse tissue-resident macrophge samples. 6 cell types, 3 biological replicates per cell type.

ORGANISM(S): Mus musculus

SUBMITTER: Yan Ma

PROVIDER: E-GEOD-24258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene signatures reflect the marked heterogeneity of tissue-resident macrophages.

Gorgani Nick N NN Ma Yan Y Clark Hilary F HF

Immunology and cell biology 20071113 3

Tissue-resident macrophages play an important role in defense against pathogens and perform key functions in organ homeostasis, innate and adaptive immunity. Tissue macrophages originate from blood monocytes that infiltrate virtually every organ in the body. Macrophages in different tissues share many characteristics, including their ability to migrate, phagocytose particles, metabolize lipids and present antigens. Morphologically they are quite heterogeneous, and some distinct functions have be ...[more]

PMID: 17998916

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