Molecular mechanism underline immune cell type population shift upon anti-DLL4 treatment
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wen Zhang
PROVIDER: E-GEOD-24296 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
Billiard Fabienne F Lobry Camille C Darrasse-Jèze Guillaume G Waite Janelle J Liu Xia X Mouquet Hugo H DaNave Amanda A Tait Michelle M Idoyaga Juliana J Leboeuf Marylène M Kyratsous Christos A CA Burton Jacquelynn J Kalter Julie J Klinakis Apostolos A Zhang Wen W Thurston Gavin G Merad Miriam M Steinman Ralph M RM Murphy Andrew J AJ Yancopoulos George D GD Aifantis Iannis I Skokos Dimitris D
The Journal of experimental medicine 20120430 5
Delta-like ligand 4 (Dll4)-Notch signaling is essential for T cell development and alternative thymic lineage decisions. How Dll4-Notch signaling affects pro-T cell fate and thymic dendritic cell (tDC) development is unknown. We found that Dll4 pharmacological blockade induces accumulation of tDCs and CD4(+)CD25(+)FoxP3(+) regulatory T cells (T(reg) cells) in the thymic cortex. Both genetic inactivation models and anti-Dll4 antibody (Ab) treatment promote de novo natural T(reg) cell expansion by ...[more]
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