Microarray analysis of V. cholerae genes differentially expressed in 12 h rabbit ileal loop mucus
Ontology highlight
ABSTRACT:
ORGANISM(S): Vibrio cholerae
SUBMITTER: Nadia Dolganov
PROVIDER: E-GEOD-24406 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine.
Nielsen Alex T AT Dolganov Nadia A NA Rasmussen Thomas T Otto Glen G Miller Michael C MC Felt Stephen A SA Torreilles Stéphanie S Schoolnik Gary K GK
PLoS pathogens 20100916 9
A fundamental, but unanswered question in host-pathogen interactions is the timing, localization and population distribution of virulence gene expression during infection. Here, microarray and in situ single cell expression methods were used to study Vibrio cholerae growth and virulence gene expression during infection of the rabbit ligated ileal loop model of cholera. Genes encoding the toxin-coregulated pilus (TCP) and cholera toxin (CT) were powerfully expressed early in the infectious proces ...[more]
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