Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Richard White
PROVIDER: E-GEOD-24528 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
White Richard Mark RM Cech Jennifer J Ratanasirintrawoot Sutheera S Lin Charles Y CY Rahl Peter B PB Burke Christopher J CJ Langdon Erin E Tomlinson Matthew L ML Mosher Jack J Kaufman Charles C Chen Frank F Long Hannah K HK Kramer Martin M Datta Sumon S Neuberg Donna D Granter Scott S Young Richard A RA Morrison Sean S Wheeler Grant N GN Zon Leonard I LI
Nature 20110301 7339
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E) (which encodes an amino acid substitution mutant of BRAF) in the neural cres ...[more]