Tet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kristine Williams
PROVIDER: E-GEOD-24843 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
Williams Kristine K Christensen Jesper J Pedersen Marianne Terndrup MT Johansen Jens V JV Cloos Paul A C PA Rappsilber Juri J Helin Kristian K
Nature 20110413 7347
Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl group of mC, converting it to 5-hydroxymethyl cytosine (hmC). Here we show that TET1 binds throughout the genome of embryonic stem cells, with the majority of binding sites located at transcription start sites (TSSs) of CpG-rich promoters and within genes. The hmC modification is found in gen ...[more]
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