Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jennifer Barb
PROVIDER: E-GEOD-24869 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes.
Chen L Y LY Eberlein M M Alsaaty S S Martinez-Anton A A Barb J J Munson P J PJ Danner R L RL Liu Y Y Logun C C Shelhamer J H JH Woszczek G G
Allergy 20110524 10
<h4>Background</h4>Leukotriene B(4) (LTB(4)) and cysteinyl leukotrienes (cysLTs) are important immune mediators, often found concomitantly at sites of inflammation. Although some of the leukotriene-mediated actions are distinctive (e.g., bronchial constriction for cysLTs), many activities such as leukocyte recruitment to tissues and amplification of inflammatory responses are shared by both classes of leukotrienes.<h4>Objective</h4>We used human monocytes to characterize leukotriene-specific sig ...[more]
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