Amiloride modulates alternative splicing in leukemic cells and re-sensitizes Bcr-AblT315I mutant cells to imatinib
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: wen-hsin chang
PROVIDER: E-GEOD-24976 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib.
Chang Wen-Hsin WH Liu Ta-Chih TC Yang Wen-Kuang WK Lee Chien-Chih CC Lin Yi-Hsiung YH Chen Tsai-Yun TY Chang Jan-Gowth JG
Cancer research 20110111 2
The antihypertensive drug amiloride is being considered as a tactic to improve cancer therapy including that for chronic myelogenous leukemia. In this study, we show that amiloride modulates the alternative splicing of various cancer genes, including Bcl-x, HIPK3, and BCR/ABL, and that this effect is not mainly related to pH alteration, which is a known effect of the drug. Splice modulation involved various splicing factors, with the phosphorylation state of serine-arginine-rich (SR) proteins al ...[more]
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