Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Attila Szanto
PROVIDER: E-GEOD-25088 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Szanto Attila A Balint Balint L BL Nagy Zsuzsanna S ZS Barta Endre E Dezso Balazs B Pap Attila A Szeles Lajos L Poliska Szilard S Oros Melinda M Evans Ronald M RM Barak Yaacov Y Schwabe John J Nagy Laszlo L
Immunity 20101101 5
Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory milieu show cell type specification as a result of altered gene expression. We demonstrate here a mechanism how inflammatory molecules modulate PPARγ signaling in distinct subsets of cells. Proinflammatory molecules inhibited whereas interleukin-4 (IL-4) st ...[more]