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Cells isolated from diaphragm of mdx mouse: satellite cells vs. PDGFRa+ cells

ABSTRACT: Transcriptional profiling of mouse skeletal muscle-derived cells comparing satellite cells with PDGFRa+ cells. Satellite cells and PDGFRa+ cells were directly isolated from diaphragm of dystrophic mdx mouse by FACS. Two-condition experiment, satellite cells vs. PDGFRa+ cells. Freshly isolated. One replicate per array.

ORGANISM(S): Mus musculus

SUBMITTER: Satoshi Kondo

PROVIDER: E-GEOD-25258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle.

Uezumi Akiyoshi A Ito Takahito T Morikawa Daisuke D Shimizu Natsuko N Yoneda Tomohiro T Segawa Masashi M Yamaguchi Masahiko M Ogawa Ryo R Matev Miroslav M MM Miyagoe-Suzuki Yuko Y Takeda Shin'ichi S Tsujikawa Kazutake K Tsuchida Kunihiro K Yamamoto Hiroshi H Fukada So-ichiro S

Journal of cell science 20111101 Pt 21

Accumulation of adipocytes and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies. The origin of these cells had been largely unknown, but recently we identified mesenchymal progenitors positive for platelet-derived growth factor receptor alpha (PDGFRα) as the origin of adipocytes in skeletal muscle. However, the origin of muscle fibrosis remains largely unknown. In this study, clonal analyses show that PDGFRα(+) cells also differentiate into collagen type-I-producing ...[more]

PMID: 22045730

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