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DNA methylation profiling of somatic tissues from normal and trisomic fetuses

ABSTRACT: The DNA methylation profiles in normal and abnormal fetal development were investigated using Illumina GoldenGate Methylation Cancer Panel I. DNA methylation status of 1505 CpG dinucleotides located in the regulatory regions of 807 genes was measured in 5 somatic tissues (brain, kidney, lung, muscle and skin) from second-trimester elective terminations of eight normal, five trisomy 21 and four trisomy 18 fetuses. Bisulfite-converted DNA from 60 samples were hybridized to the Illumina GoldenGate Methylation Cancer Panel I array.

ORGANISM(S): Homo sapiens

SUBMITTER: Ryan Yuen 

PROVIDER: E-GEOD-25283 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Extensive epigenetic reprogramming in human somatic tissues between fetus and adult.

Yuen Ryan Kc RK   Neumann Sarah Ma SM   Fok Alexandra K AK   Peñaherrera Maria S MS   McFadden Deborah E DE   Robinson Wendy P WP   Kobor Michael S MS  

Epigenetics & chromatin 20110505

<h4>Background</h4>Development of human tissue is influenced by a combination of intrinsic biological signals and extrinsic environmental stimuli, both of which are mediated by epigenetic regulation, including DNA methylation. However, little is currently known of the normal acquisition or loss of epigenetic markers during fetal and postnatal development.<h4>Results</h4>The DNA methylation status of over 1000 CpGs located in the regulatory regions of nearly 800 genes was evaluated in five somati  ...[more]

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