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Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

ABSTRACT: The Illumina GoldenGate® methylation array was used to evaluate DNA methylation at 1,505 CpG sites in 807 cancer-related genes in 91 consecutive CRC samples and 28 matched normal colonic mucosa. Bisulphite converted DNA from the 119 samples (91 CRC, 28 matched normals) were hybridised to the Illumina GoldenGate® methylation array.

ORGANISM(S): Homo sapiens

SUBMITTER: Marie Loh 

PROVIDER: E-GEOD-39446 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.

Ang Pei Woon PW   Loh Marie M   Liem Natalia N   Lim Pei Li PL   Grieu Fabienne F   Vaithilingam Aparna A   Platell Cameron C   Yong Wei Peng WP   Iacopetta Barry B   Soong Richie R  

BMC cancer 20100521

<h4>Background</h4>Most previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups.<h4>Methods</h4>DNA methylation at 1,505 CpG sites in 807 cancer-related genes was evaluated using the Illumina GoldenGate methylation array in 28 normal colonic mucosa and 91 consecutive CRC sam  ...[more]

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