Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Fedik Rahimov
PROVIDER: E-GEOD-25306 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Physiological genomics 20110125 8
Inhibition of the myostatin signaling pathway is emerging as a promising therapeutic means to treat muscle wasting and degenerative disorders. Activin type IIB receptor (ActRIIB) is the putative myostatin receptor, and a soluble activin receptor (ActRIIB-Fc) has been demonstrated to potently inhibit a subset of transforming growth factor (TGF)-β family members including myostatin. To determine reliable and valid biomarkers for ActRIIB-Fc treatment, we assessed gene expression profiles for quadri ...[more]