Transcriptomics

Dataset Information

0

Sex-specific Phenotypes modulated by activin in pancreatic cancer cachexia and mortality


ABSTRACT: Cachexia frequently develops in patients with pancreatic ductal adenocarcinoma (PDAC) and contributes to cancer deaths.Sex differences have been observed in cancer cachexia; however, the underlying molecular mechanisms are far less addressed. We assessed sex difference in PDAC cachexia phenotypes in the KPC (Kras-G12D;Trp-R172H;Pdx1::Cre) genetically engineered mouse model of PDAC and profiled gene expression in the quadriceps skeletal muscles. Males with PDAC experienced earlier cachexia-onset than the female counterpart and activin blockade by ACVR2B/Fc reduced cachexia sympotomes in males but not females. PDAC induced earlier global transcritome alterations in males than females.

ORGANISM(S): Mus musculus

PROVIDER: GSE157251 | GEO | 2022/05/10

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-04-07 | GSE123310 | GEO
2023-11-08 | GSE245227 | GEO
2023-11-08 | GSE245493 | GEO
2022-09-30 | GSE205093 | GEO
2025-01-08 | GSE276018 | GEO
2020-06-16 | GSE142467 | GEO
2014-09-26 | GSE60151 | GEO
2011-08-29 | E-GEOD-24112 | biostudies-arrayexpress
2024-03-11 | GSE226898 | GEO
2024-04-09 | PXD036752 | Pride