Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Haesler
PROVIDER: E-GEOD-25480 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Weber Silvio S Niessen Michaela T MT Prox Johannes J Lüllmann-Rauch Renate R Schmitz Annika A Schwanbeck Ralf R Blobel Carl P CP Jorissen Ellen E de Strooper Bart B Niessen Carien M CM Saftig Paul P
Development (Cambridge, England) 20110201 3
The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address the in vivo relevance of Adam10 in the epidermis, we have selectively disrupted Adam10 during skin morphogenesis and in adult skin. K14-Cre driven epidermal Adam10 deletion leads to perinatal lethality, barrier impairment and absence of sebaceous glands. A reduction of spinous layers, not associated with differences in either p ...[more]