Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sandra Schmitz
PROVIDER: E-GEOD-41174 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Albert Mareike M Schmitz Sandra U SU Kooistra Susanne M SM Malatesta Martina M Morales Torres Cristina C Rekling Jens C JC Johansen Jens V JV Abarrategui Iratxe I Helin Kristian K
PLoS genetics 20130418 4
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized cr ...[more]