Unknown,Transcriptomics,Genomics,Proteomics

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The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Sandra Schmitz 

PROVIDER: E-GEOD-41174 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.

Albert Mareike M   Schmitz Sandra U SU   Kooistra Susanne M SM   Malatesta Martina M   Morales Torres Cristina C   Rekling Jens C JC   Johansen Jens V JV   Abarrategui Iratxe I   Helin Kristian K  

PLoS genetics 20130418 4


Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized cr  ...[more]

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