Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Tobias Herold
PROVIDER: E-GEOD-25571 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Herold Tobias T Jurinovic Vindi V Mulaw Medhanie M Seiler Till T Dufour Annika A Schneider Stephanie S Kakadia Purvi M PM Feuring-Buske Michaela M Braess Jan J Spiekermann Karsten K Mansmann Ulrich U Hiddemann Wolfgang W Buske Christian C Bohlander Stefan K SK
Genes, chromosomes & cancer 20110415 7
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is not known. We examined the 13q14 and 11q22-23 minimally deleted regions (MDRs) for differentially expressed genes by analyzing 154 microarray CLL gene expression data sets. We were able to generate a de ...[more]