Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kristen Brennand
PROVIDER: E-GEOD-25673 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Brennand Kristen J KJ Simone Anthony A Jou Jessica J Gelboin-Burkhart Chelsea C Tran Ngoc N Sangar Sarah S Li Yan Y Mu Yangling Y Chen Gong G Yu Diana D McCarthy Shane S Sebat Jonathan J Gage Fred H FH
Nature 20110413 7346
Schizophrenia (SCZD) is a debilitating neurological disorder with a world-wide prevalence of 1%; there is a strong genetic component, with an estimated heritability of 80-85%. Although post-mortem studies have revealed reduced brain volume, cell size, spine density and abnormal neural distribution in the prefrontal cortex and hippocampus of SCZD brain tissue and neuropharmacological studies have implicated dopaminergic, glutamatergic and GABAergic activity in SCZD, the cell types affected in SCZ ...[more]