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Murine CD8+ Pmel Lymphocytes IL-2 vs. IL-15

ABSTRACT: Central memory tumor-reactive CD8+ T cells confer superior antitumor immunity compared to effector memory T cells

ORGANISM(S): Mus musculus

SUBMITTER: Keith Kerstann

PROVIDER: E-GEOD-2578 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.

Klebanoff Christopher A CA Gattinoni Luca L Torabi-Parizi Parizad P Kerstann Keith K Cardones Adela R AR Finkelstein Steven E SE Palmer Douglas C DC Antony Paul A PA Hwang Sam T ST Rosenberg Steven A SA Waldmann Thomas A TA Restifo Nicholas P NP

Proceedings of the National Academy of Sciences of the United States of America 20050624 27

Central memory CD8+ T cells (T(CM)) and effector memory CD8+ T cells (T(EM)) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo. Further, the ability of T(CM) to treat an established tumor or infection has yet to be evaluated. To address the therapeutic potential of different tumor-reactive CD8+ T cell memory subsets, we used an established model for the in vitro generation of T(CM) and T(EM) by using IL-15 and IL-2, resp ...[more]

PMID: 15980149

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Murine CD8+ Pmel Lymphocytes IL-2 vs. IL-15

Project description:Central memory tumor-reactive CD8+ T cells confer superior antitumor immunity compared to effector memory T cells Keywords: other

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