Unknown,Transcriptomics,Genomics,Proteomics

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Non-cancerous liver infiltrating lymphocytes of hepatitis C and tumor-infiltrating lymphocytes

ABSTRACT: Study goal is to disclose features of gene expressio profile of non-cancerous liver-infiltrating lymphocytes of type C hepatitis patients with hepatocellular carcinomas and tumor-infiltrating lymphocytes of type C hepatitis patients with hepatocellular carcinomas. Keywords: gene expression profile, non-cancerous liver-infiltrating lymphocytes, tumor-infiltrating lymphocytes, type C hepatitis, hepatocellular carcinoma Non-cancerous liver-infiltrating lymphocytes were obtained by laser capture microdissection from surgically resected liver tissues of 12 type C hepatitis patients with hepatocellular carcinoma. The mRNA was amplified and expression profile was comprehensively analyzed with reference RNA using oligo-DNA chip. Tumor-infiltrating lymphocytes were obtained by laser capture microdissection from surgically resected cancer tissues of 12 type C hepatitis patients with hepatocellular carcinoma. The mRNA was amplified and expression profile was comprehensively analyzed with reference RNA using oligo-DNA chip.

ORGANISM(S): Homo sapiens

SUBMITTER: Masao Honda 

PROVIDER: E-GEOD-10461 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Common transcriptional signature of tumor-infiltrating mononuclear inflammatory cells and peripheral blood mononuclear cells in hepatocellular carcinoma patients.

Sakai Yoshio Y   Honda Masao M   Fujinaga Haruo H   Tatsumi Isamu I   Mizukoshi Eishiro E   Nakamoto Yasunari Y   Kaneko Shuichi S  

Cancer research 20081201 24

Hepatocellular carcinoma (HCC) is frequently associated with infiltrating mononuclear inflammatory cells. We performed laser capture microdissection of HCC-infiltrating and noncancerous liver-infiltrating mononuclear inflammatory cells in patients with chronic hepatitis C (CH-C) and examined gene expression profiles. HCC-infiltrating mononuclear inflammatory cells had an expression profile distinct from noncancerous liver-infiltrating mononuclear inflammatory cells; they differed with regard to  ...[more]

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