Genetic instability in colon cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jonathan Pollack
PROVIDER: E-GEOD-2591 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A gene expression signature of genetic instability in colon cancer.
Giacomini Craig P CP Leung Suet Yi SY Chen Xin X Yuen Siu Tsan ST Kim Young H YH Bair Eric E Pollack Jonathan R JR
Cancer research 20051001 20
Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in the context of colon cancer, where MSI tumors represent approximately 15% of cases, and compared with MSS tumors, more often arise in the proximal colon and display favorable clinical outcome. To further explore molecular differences, we profiled gene ...[more]
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