Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Richard Koche
PROVIDER: E-GEOD-26099 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Koche Richard P RP Smith Zachary D ZD Adli Mazhar M Gu Hongcang H Ku Manching M Gnirke Andreas A Bernstein Bradley E BE Meissner Alexander A
Cell stem cell 20110101 1
Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem cell (iPSC) state, many mechanistic questions still remain. To gain insight into the earliest events in the reprogramming process, we systematically analyzed the transcriptional and epigenetic changes that occur during early factor induction after discrete numbers of divisions. We observed rapid, genome-wide changes in the euchromatic histone modification, H3K4me2, a ...[more]