Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kornelia Polyak
PROVIDER: E-GEOD-26139 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Maruyama Reo R Choudhury Sibgat S Kowalczyk Adam A Bessarabova Marina M Beresford-Smith Bryan B Conway Thomas T Kaspi Antony A Wu Zhenhua Z Nikolskaya Tatiana T Merino Vanessa F VF Lo Pang-Kuo PK Liu X Shirley XS Nikolsky Yuri Y Sukumar Saraswati S Haviv Izhak I Polyak Kornelia K
PLoS genetics 20110421 4
Differentiation is an epigenetic program that involves the gradual loss of pluripotency and acquisition of cell type-specific features. Understanding these processes requires genome-wide analysis of epigenetic and gene expression profiles, which have been challenging in primary tissue samples due to limited numbers of cells available. Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, as well as gene expression patterns of normal ...[more]