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Genomic profiles vary with race and subtype in young African American and European American breast cancer (SNP)

ABSTRACT: In the United States, African-American (AA) women are more likely to develop early-onset breast cancer and have historically poorer outcomes due to this disease compared to European-American (EA) women. Here, we analyzed genomic profiles of breast tumors from young women (<50 years old), matched by tumor subtype, histological grade, and ethnicity (African-American, AA, compared to European-American, EA). DNA copy number alterations (CNAs) were analyzed on the Affymetrix Human SNP Array v 6.0 platform. The study provides insight into the genetic component of ethnicity-related breast cancer health disparities. DNA copy number alterations (CNAs) and genotypes were analyzed using the Affymetrix SNP 6.0 platform. Breast tumor samples from young women (< 50 years old) were matched as follows: a matched pair consists of one AA and one EA sample, matched for tumor grade and tumor subtype (based on immunohistochemical analysis of ER, PR, and HER2 status). DNA from forty-four samples (22 AA, 22 EA) was analyzed on the Affymetrix SNP 6.0 array according to manufacturer’s directions.

ORGANISM(S): Homo sapiens

SUBMITTER: Theresa Strong

PROVIDER: E-GEOD-26232 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic profiles vary with race and subtype in young African American and European American breast cancer (SNP)

2013-01-29 | GSE26232 | GEO

Genomic profiles vary with race and subtype in young African American and European American breast cancer (aCGH)

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Genomic profiles vary with race and subtype in young African American and European American breast cancer (aCGH)

Project description:In the United States, African-American (AA) women are more likely to develop early-onset breast cancer and have historically poorer outcomes due to this disease compared to European-American (EA) women. Here, we analyzed genomic profiles of breast tumors from young women (<50 years old), matched by tumor subtype, histological grade, and ethnicity (African-American, AA, compared to European-American, EA). DNA copy number alterations (CNAs) were analyzed using a 32K BAC tiling path array. The study provides insight into the genetic component of ethnicity-related breast cancer health disparities. Breast tumor samples from young women (< 50 years old) were matched as follows: a matched pair consists of one AA and one EA sample, matched for tumor grade and tumor subtype (based on immunohistochemical analysis of ER, PR, and HER2 status). 44 experiments; each experiment is tumor DNA versus reference control DNA (AF) isolated from the blood of a 25-year-old African-American female with no familial or personal history of breast cancer. Additional control experiments included the AF reference versus the well-characterized F1 reference, and 3 self-self hybridization controls (AF versus AF).

2013-01-29 | E-GEOD-26214 | biostudies-arrayexpress

Copy number profiling of prostate cancers from 40 African American patients

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Gene expression profiling of African-American prostate cancer

Project description:African-American (AA) men have both a higher incidence and significantly higher mortality rates from prostate cancer (PCa) than European American (EA) men. In this study we have carried out a detailed analysis of both CNAs and gene expression changes in PCas from AA men compared to their matched benign tissues. We have identified MNX1 as a novel androgen regulated oncogene that is upregulated to a greater degree in AA PCa compared to EA PCa. Furthermore, RGS12 is a novel tumor suppressor on 4p16.3 that is preferentially deleted in AA PCa which negatively regulates MNX1 expression.

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MicroRNA expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients

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2009-08-07 | E-GEOD-17356 | biostudies-arrayexpress

Expression data from prostate cancer epithelial cells from African American and European American men

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Gene expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients

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2015-07-27 | E-GEOD-64331 | biostudies-arrayexpress

Gene expression profiling of African American vs European American HPV-negative oropharyngeal squamous cell carcinomas

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