Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Di Guglielmo
PROVIDER: E-GEOD-26241 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of cell science 20150201 3
Transforming growth factor b (TGFb) signaling controls many cellular responses including proliferation, epithelial to mesenchymal transition and apoptosis, through the activation of canonical (Smad) as well as non-canonical (e.g., Par6) pathways. Previous studies from our lab have demonstrated that aPKC inhibition regulates TGFb receptor trafficking and signaling. Here, we report that downstream TGFb-dependent transcriptional responses in aPKC-silenced NSCLC cells were reduced compared with thos ...[more]