Rejuvenation of pluripotent stem cells by frequent activation of Zscan4
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Minoru Ko
PROVIDER: E-GEOD-26278 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Zscan4 restores the developmental potency of embryonic stem cells.
Amano Tomokazu T Hirata Tetsuya T Falco Geppino G Monti Manuela M Sharova Lioudmila V LV Amano Misa M Sheer Sarah S Hoang Hien G HG Piao Yulan Y Stagg Carole A CA Yamamizu Kohei K Akiyama Tomohiko T Ko Minoru S H MS
Nature communications 20130101
The developmental potency of mouse embryonic stem (ES) cells, which is the ability to contribute to a whole embryo, is known to deteriorate during long-term cell culture. Previously, we have shown that ES cells oscillate between Zscan4(-) and Zscan4(+) states, and the transient activation of Zscan4 is required for the maintenance of telomeres and genome stability of ES cells. Here we show that increasing the frequency of Zscan4 activation in mouse ES cells restores and maintains their developmen ...[more]
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