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Defining a developmental path to neural fate by global expression profiling of mouse ESCs and adult NS cells


ABSTRACT: Defining a developmental path to neural fate by global expression profiling of mouse embryonic stem cells and adult neural stem/progenitor cells. This SuperSeries is composed of the following subset Series: GSE4075: Neural induction (Embrioid bodies-Retinoic acid) GSE4076: Neural induction (N2B27 monolayer cluture) GSE4077: ES, EC, NS, TS, Placenta and Neural induction (N2B27) comaprison Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Angelo Vescovi 

PROVIDER: E-GEOD-4082 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Defining a developmental path to neural fate by global expression profiling of mouse embryonic stem cells and adult neural stem/progenitor cells.

Aiba Kazuhiro K   Sharov Alexei A AA   Carter Mark G MG   Foroni Chiara C   Vescovi Angelo L AL   Ko Minoru S H MS  

Stem cells (Dayton, Ohio) 20051215 4


To understand global features of gene expression changes during in vitro neural differentiation, we carried out the microarray analysis of embryonic stem cells (ESCs), embryonal carcinoma cells, and adult neural stem/progenitor (NS) cells. Expression profiling of ESCs during differentiation in monolayer culture revealed three distinct phases: undifferentiated ESCs, primitive ectoderm-like cells, and neural progenitor cells. Principal component (PC) analysis revealed that these cells were aligned  ...[more]

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