MiRNA expression in zebrafish tissues
Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Wigard Kloosterman
PROVIDER: E-GEOD-2628 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MicroRNA expression in zebrafish embryonic development.
Wienholds Erno E Kloosterman Wigard P WP Miska Eric E Alvarez-Saavedra Ezequiel E Berezikov Eugene E de Bruijn Ewart E Horvitz H Robert HR Kauppinen Sakari S Plasterk Ronald H A RH
Science (New York, N.Y.) 20050526 5732
MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in zebrafish embryos by microarrays and by in situ hybridizations, using locked-nucleic acid-modified oligonucleotide probes. Most miRNAs were expressed in a highly tissue-s ...[more]
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