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Transcription profiling of proximal and distal muscle groups in dysferlin-deficient mice (C57BL/10.SJL_Dysf) to understand selective pattern of muscle involvement in muscular dystrophies

ABSTRACT: By comparing the transcriptome from proximal (quadriceps femoris, QF) and distal (tibialis anterior, TA)muscle groups in dysferlin deficient mouse muscle (the SJL mutation bred onto C57BL/10 to produces C57BL/10.SJL_Dysf) with proximal and distal muscle groups from control C57BL/10 mice of an equivalent age (3-weeks old, prior to the onset of overt pathology) we aim to address the issues of muscle selectivity in this this form of muscular dystrophy.

ORGANISM(S): Mus musculus

SUBMITTER: Steve Laval

PROVIDER: E-GEOD-2629 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The differential gene expression profiles of proximal and distal muscle groups are altered in pre-pathological dysferlin-deficient mice.

von der Hagen Maja M Laval Steven H SH Cree Lynsey M LM Haldane Faye F Pocock Matthew M Wappler Ilka I Peters Heiko H Reitsamer Herbert A HA Hoger Harald H Wiedner Maria M Oberndorfer Felicitas F Anderson Louise V B LV Straub Volker V Bittner Reginald E RE Bushby Kate M D KM

Neuromuscular disorders : NMD 20051108 12

The selective pattern of muscle involvement is a key feature of muscular dystrophies. Dysferlinopathy is a good model for studying this process since it shows variable muscle involvement that can be highly selective even in individual patients. The transcriptomes of proximal and distal muscles from wildtype C57BL/10 and dysferlin deficient C57BL/10.SJL-Dysf mice at a prepathological stage were assessed using the Affymetrix oligonucleotide-microarray system. We detected significant variation in g ...[more]

PMID: 16288871

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Dysferlin deficiency modulates the proximal-distal muscle transcriptome

Project description:By comparing the transcriptome from proximal (quadriceps femoris, QF) and distal (tibialis anterior, TA)muscle groups in dysferlin deficient mouse muscle (the SJL mutation bred onto C57BL/10 to produces C57BL/10-SJL.Dysf) with proximal and distal muscle groups from control C57BL/10 mice of an equivalent age (3-weeks old, prior to the onset of overt pathology) we aim to address the issues of muscle selectivity in this this form of muscular dystrophy. Keywords: parallel sample

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Mus musculus

Project description:Dysferlin deficiency modulates the proximal-distal muscle transcriptome

| PRJNA92145 | ENA

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