Distinct Sets of Genetic Alterations in Melanoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: P LeBoit
PROVIDER: E-GEOD-2631 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Distinct sets of genetic alterations in melanoma.
Curtin John A JA Fridlyand Jane J Kageshita Toshiro T Patel Hetal N HN Busam Klaus J KJ Kutzner Heinz H Cho Kwang-Hyun KH Aiba Setsuya S Bröcker Eva-Bettina EB LeBoit Philip E PE Pinkel Dan D Bastian Boris C BC
The New England journal of medicine 20051101 20
<h4>Background</h4>Exposure to ultraviolet light is a major causative factor in melanoma, although the relationship between risk and exposure is complex. We hypothesized that the clinical heterogeneity is explained by genetically distinct types of melanoma with different susceptibility to ultraviolet light.<h4>Methods</h4>We compared genome-wide alterations in the number of copies of DNA and mutational status of BRAF and N-RAS in 126 melanomas from four groups in which the degree of exposure to ...[more]
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