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Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis

ABSTRACT: Endometriosis is defined as the presence of endometrial tissue (eutopic tissue) outside the uterus (ectopic tissue). We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium. Comparison of paired eutopic/ectopic endometrium microRNAs from three patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Ilaria Gregnanin

PROVIDER: E-GEOD-26346 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis.

Filigheddu Nicoletta N Gregnanin Ilaria I Porporato Paolo E PE Surico Daniela D Perego Beatrice B Galli Licia L Patrignani Claudia C Graziani Andrea A Surico Nicola N

Journal of biomedicine & biotechnology 20100310

Endometriosis, defined as the presence of endometrial tissue outside the uterus, is a common gynecological disease with poorly understood pathogenesis. MicroRNAs are members of a class of small noncoding RNA molecules that have a critical role in posttranscriptional regulation of gene expression by repression of target mRNAs translation. We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium in 3 patients through microarray analysis. We identified ...[more]

PMID: 20300586

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